Poster Presentation 12th Australasian Virology Society Meeting 2024

Genetic diversity of Porcine Reproductive and Respiratory Syndrome Virus in Korea from 2018 to 2022 (#265)

Su-Hwa YOU 1 , Seok-Jin Kang 1 , Yun Sang Cho 1 , Hyang-Sim Lee 1 , Yeun-Kyung Shin 1
  1. Animal and Plant Quarantine Agency, Gimcheon-si, South Korea

Porcine Reproductive and respiratory syndrome (PRRS) is stands as one of the most important significant infectious diseases and endemic disease on swine farm in the Republic of Korea. Belonging to the family Arteriviridae and the other within the order Nidovirales, and has two species; PRRSV-1 comprises two species: PRRSV-1 (Betaarterivirus suid 1, EU genotype,) and PRRSV-2(Betaarterivirus suid 2, North American genotype,). These two genotypes exhibits significant genetic diversity,  between the two genotypes sharing only approximately 60% nucleotide similarity. Both PRRSV-1 and PRRSV-2 are currently circulating in Korean swine herds, with PRRSV-1 predominantly represented by  in Korea. PRRSV-1 strain is majority subtype 1-A, and subtype 1-C, while . PRRSV-2 strains are classified into lineage 1, 5, and 8, as well as and Korean strain (LKA , LKB, and LKC). In this study, We aimed to investigated the prevalence and genetic diversity of PRRSV strain by using the ORF7 and , ORF5 genes analysis analyses. ORF5 RT-PCR revealed 1847 positive samples tested positive for PRRSV. The prevalence of PRRSV-1, PRRSV-2 and co-infection that of both PRRSV-1 and PRRSV-2 based on ORF5 was 42%, 52%, and 6%, respectively, from 2018 to 2022. Within the PRRSV-1 group,  suggest that subgroup 1-A (89%) was predominant followed by Subgroup1-C (11%). Analysis of the PRRSV-2 group was analyzed revealed to lineage 1(40%), lineage 5(27%), lineage 8(1%), LKA (2%), LKB (12%), and LKC (17%). Continuous Surveillance of PRRSV types is critical crucial to tailor effective control measures. Ongoing surveillance is necessary to identify the current circulating virus strain in circulation is necessary to design a for vaccine design. A systemic comprehensive immunization program, utilizing with region-specific vaccinations and alongside stringent biosecurity measures, is required imperative to mitigate reduce PRRSV infections in the Republic of Korea.

  1. Lee MA, Jayaramaiah U, You SH, Shin EG, Song SM, Ju L, Kang SJ, Hyun BH, Lee HS. Molecular Characterization of Porcine Reproductive and Respiratory Syndrome Virus in Korea from 2018 to 2022. Pathogens. 2023 May 24;12(6):757. doi: 10.3390/pathogens12060757. PMID: 37375447; PMCID: PMC10303207.