Wednesday, 4th December 12th Australasian Virology Society Meeting 2024

• The Era of RNA Medicines to treat viral infections  - Nigel A J McMillan
• Using spatial transcriptomics to uncover the immune mechanisms of microarray patch vaccination - Christopher LD McMillan
• Using oncolytic viruses to save Tasmanian devils from transmissible facial tumours - Anjali Gowripalan
• A novel chimeric coronavirus spike combining SARS-CoV-2 RBD and scaffold domains from HKU-1 elicits potent neutralising antibody responses - Hyon-Xhi Tan
• Multivalent T cell vaccine against Zika virus - Branka Grubor-Bauk

• Drivers of diversity in the virosphere  - Jemma Geoghegan
• Rapid Tracking of Avian Influenza Outbreaks in Australian Poultry - Matthew Neave
• Induction and antiviral activity of bovine interferon stimulated genes against bovine herpesviruses and influenza viruses. - Rubaiyea Farrukee
• Salt Gully virus: a novel henipavirus isolated from Australian pteropus bats - Jennifer A Barr
• Australian terrestrial environments harbour extensive RNA virus diversity - Sabrina Sadiq

• The Architecture of the Baculovirus Nucleocapsid Defines the Hallmarks of a New Viral Realm - Joshua M Hardy
• The association and molecular mechanism behind asymptomatic SARS-CoV-2 infection - Dimitra SM Chatzileontiadou
• Reviewing the Structural Conservation of SARS-related Coronavirus Spike Glycoproteins Through Cryo-EM - Francesca R. Hills
• High-resolution structure of the Circovirus replication associated protein - Babu Nath
• Chimeric viral platform enables high-resolution cryo-EM analysis and antigenic characterization of diverse pathogenic tick-borne flaviviruses. - Natalee Newton

• Isolation and characterization of the first mammalian associated chu-like virus from Tasmanian devil tumor cells - Julien Melade
• Phylogenomics of Murray Valley encephalitis genotypes of the 2023 Australian outbreak - Jackie E Mahar
• Understanding the nuclear localisation of cytomegalovirus major immediate early proteins through their interactions with host factors - Sophie Wacher
• Potent neutralising monoclonal antibodies against human coronavirus NL63 - Robyn Esterbauer
• Development of an mRNA-LNP vaccine to prevent against HTLV-1 subtype C infection. - Samantha L Grimley
• Superior Efficacy of the High Density Microarray Patch for Delivering a Novel Zika DNA Vaccine Targeting Non-structural Protein 1 - Danushka K Wijesundara
• Natural killer cells in children with obesity have a ‘trained’ immune phenotype and heightened pro-inflammatory responses to ex vivo influenza A virus stimulation - Ellesandra C Noye
• Investigating HBV DNA integration and its role in genomic instability through HBx expression - Dong Li

• Chronic co-morbidities in people with HIV: Getting to the heart of the problem - Anna Hearps
• Ferret Precision-Cut Lung Slices: Development of a High-throughput ex-vivo model to Study Influenza Virus Infection - Ashwin Muraleetharan
• Cardiovascular symptoms of PASC are associated with trace-level circulatory cytokines that affect the function of primary human cardiomyocytes - Jane E Sinclair
• Defective viral genomes produced during Ebola virus infection induce a potent antiviral response in vitro - Rebecca Johnson
• An in situ quantitative map of initial immune cell dynamics during human colorectal HIV transmission - Thomas R O'Neil

A light snack and beverages will be provided.

Oral presentation posters

Isolation and characterization of the first mammalian associated chu-like virus from Tasmanian devil tumor cells (102) - Julien Melade
Phylogenomics of Murray Valley encephalitis genotypes of the 2023 Australian outbreak (104) - Jackie E Mahar
Understanding the nuclear localisation of cytomegalovirus major immediate early proteins through their interactions with host factors (106) - Sophie Wacher
Potent neutralising monoclonal antibodies against human coronavirus NL63 (108) - Robyn Esterbauer
Development of an mRNA-LNP vaccine to prevent against HTLV-1 subtype C infection. (110) - Samantha L Grimley
Superior Efficacy of the High Density Microarray Patch for Delivering a Novel Zika DNA Vaccine Targeting Non-structural Protein 1 (112) - Danushka K Wijesundara
Natural killer cells in children with obesity have a ‘trained’ immune phenotype and heightened pro-inflammatory responses to ex vivo influenza A virus stimulation (114) - Ellesandra C Noye
Investigating HBV DNA integration and its role in genomic instability through HBx expression (116) - Dong Li

• Cross-serotypically conserved epitope recommendations for a universal T cell-based dengue vaccine   - Syed Faraz Ahmed
• First molecular insight into HLA-C contribution to COVID-19 outcome - You Min Ahn
• SUB-OPTIMAL VACCINATION STRATEGIES CHANGE ILTV RECOMBINATION PATTERNS IN POULTRY - Turgut Esad Aktepe
• Inhibition of Akabane orthobunyavirus infection by the nuclear tranport antagonist Importazole  - Amjad Ali
• Role of NINJ1 in Influenza A-mediated cell death - Rebecca L Ambrose
• Sequestration of a pro-viral protein from Aedes aegypti by the Wolbachia surface protein may contribute to dengue virus-blocking - Sassan Asgari
• Next-gen mRNA technologies for animal vaccines - Armira Azuar
• Multiple strains of highly pathogenic avian influenza virus A (H7N3 and H7N9) detected in Victoria, Australia, 2024 - Jana Batovska
• A YFV vaccine induced human antibody broadly neutralises multiple flaviviruses and recognises a unique epitope. - Summa Bibby
• Streamlining gene editing strategies for prevention of intractable disease in livestock.  - Tatiana Briody
• Establishment of a human norovirus cultivation system and a murine system for evaluating norovirus vaccines - Thomas Burton
• The novel host long noncoding RNA-LINC2781 positively regulates innate antiviral response upon CVB5 infection by impairing the G3BP2-STAT1 interaction - Wei Chen
• Modelling & Targeting Cytokine Storm in Dengue-infected Mice - William Clow
• Identifying host factors important for Japanese encephalitis virus infection of neurons using CRISPR-Cas9 - Abigail L Cox
• Advanced culture models and molecular tools to investigate filovirus pathogenesis - Joshua Deerain
• Henipavirus matrix protein employs a non-classical nuclear localization signal binding mechanism - Camilla M Donnelly
• The Unconventional Secretion of Murine and Human Norovirus NS1 - Matthew J Edwards
• Coatomer Protein Complex I is Required for Efficient Secretion of Dengue Virus Non-structural Protein 1 - Nicholas S Eyre
• Comparative analysis of seasonal and pathogenic coronavirus infections in four physiologically relevant models of the human respiratory tract   - Matthew Gartner
• Identification of molecular factors that influence reassortment of highly pathogenic avian influenza H5 viruses - Brad Gilbertson
• SARS-CoV-2 Omicron Spike induces TGF-β signalling independent of RGD-binding integrins - Nicholas Gracie
• Identification Of Structural Features Essential For Baculovirus Capsid Assembly Through Mutagenesis and X-ray Crystallography - Jungmin Ha
• Bispecific Antibodies as Broad-Spectrum Therapeutics for Influenza - Noah Hayes
• Batting for Structure: the Shrewd Secrets of Henipavirus Fusion Proteins - Jun Jet Hen
• Replication of contemporary A(H1N1)pdm09, A(H3N2) and B Victoria lineage influenza viruses in the upper and lower respiratory tract of ferrets. - Saira Hussain
• Evaluating cell:cell antiviral protection by Wolbachia in Aedes aegypti cells - Neil Katrina D Ibay
• Epidemiology and Genetic Diversity of Coronaviruses in Rodents and Shrews in Bangladesh - Ariful Islam
• Liposome based vaccine development approaches for African Swine fever virus (ASFV) - MD Tanjir Islam
• Identifying essential viral genes for the development of a safe and effective vaccine to fight African swine fever pandemic     - Fan Jia
• Genomics-based diagnostics for infectious diseases - K M Ahsanul Kabir
• Imprinting of broadly neutralising anti-HCV antibodies - Eloise Kershler
• Molecular Mechanisms of Antiviral NLRP1 Responses in Different Skin Models - Dorothee J Lapp
• Identification of Synergistic mutations in Influenza A/H3N2 using Association Rule Mining   - Carol Lee
• Immunogenic HLA-B*44:03 restricted peptide does not induce the same response in individuals with HLA-B44 superfamily molecules    - Samuel Liwei Leong
• Characterisation of Emerging Haemorrhagic Virus Glycoproteins - Hui Yi Lim
• Evaluation eight arbovirus exposures among Papua New Guinea military personnel before 2023 by ELISA and neutralization assays - Wenjun Liu
• REAPER: Mosquito in vivo virus targeting to control viral transmission - Adam Lopez-Denman
• The Application of Genome Editing To Improve The Disease Resilience In Cattle - Ziyu Luo
• The MD compound: A novel influenza antiviral with a dual mode of action - Charley Mackenzie-kludas
• Lyophilization of Dengue Virus DIPs: A Strategy for Improved Stability and Antiviral Activity - Pramila Maniam
• Molecular drivers of JEV fitness assessed using in vitro growth kinetics and quasi-species analysis from vertebrate and invertebrate samples - Clara Maurizzi
• Characterising a novel interaction between PAIP1 and NS3 in norovirus infection - Eleanor M Mead
• Norovirus molecular epidemiology in NSW 2021 – 2023: The persistence of Sydney 2012 - Lewis K Mercer
• Mechanism of viral neutralisation of herpes simplex virus glycoprotein by monoclonal antibody 2c - Naphak Modhiran
• Characterising primary immortalised cell lines to discover host factors essential to Henipavirus infection  - Rasan Mohamed Sathiqu
• Understanding the AhR and Innate Immunity Axis in RNA Virus Infection - Xavier B Montin
• Investigation into the ability of Victorian hematophagous insects to acquire and retain lumpy skin disease virus. - Henry M Munyanduki
• Characterisation of nuclear localisation mechanisms of herpesvirus basic leucine zipper proteins    - Nadeeka Nethmini Narasinghe Arachchige
• Single-cell analysis of VACV infection reveals pathogen-driven timing of early and late phases and host-limited dynamics of virus production - Timothy P Newsome
• Phylogenetic analysis and characterisation of Murray Valley encephalitis virus (MVEV) isolates from the Ralph Doherty virus collection. - Wilson Nguyen
• The PAZ domain of Aedes aegypti Dicer 2 is critical for accurate and high-fidelity size determination of virus-derived small interfering RNAs. - Rhys Parry
• Xinyang flavivirus, from Haemaphysalis flava ticks in Henan Province, China, defines a basal, likely tick-only Orthoflavivirus clade - Rhys H. Parry
• In Silico Comparison of Omicron SARS-CoV 2 Spike Protein Binding Affinity with Rodent ACE2 Predicts that a Broad Range of Rodents are Susceptible to SARS-CoV 2 Infection - Timothy Penn
• Relocating MxA - A Broad-Spectrum Antiviral Protein - Angus Picking
• Antivirals targeting the conserved HIV-1 TIM-TAM riboswitch specifically reactivate HIV-1 from latency through modulating viral RNA-biology. - Damian Purcell
• Fitness landscape and evolutionary models for combating Hepatitis C virus - Ahmed Abdul Quadeer
• Inferring effects of mutations on SARS-CoV-2 transmission from genomic surveillance data - Ahmed Abdul Quadeer
• Defining the immunological and pathological events that distinguish lethal versus non-lethal flavivirus encephalitis - Daniel J. Rawle
• Importance of amino acid changes on Zika and Dengue viruses NS1 protein in its cell behavior and antibodies recognition. - Marjolaine ROCHE
• Testing the utility of Wolbachia as a control tool for Australian endemic mosquito-borne viruses. - Katherine Rosevear
• Innovation in Enteric Virus Research: Cell Lines and in vivo shedding models to study Adenovirus F-40/41   - Valeria M Sanders
• Boosting four-mula:  Impact of elevated IgG4 following repeated COVID-19 mRNA boosters. - Kevin J Selva
• Detection of a possible novel arbovirus of Culex spp mosquitoes - Stephen Sharpe
• Transcriptomics in virology: we are doing it wrong! Novel sequencing approach uncovers unexpected mechanisms of flavivirus neuropatogenesis. - Andrii Slonchak
• How does rabies virus prevent the production of interferon? - Hudson A Smith
• Phage therapy for deep skin wound Staphylococcus aureus infections in a murine model.  - Peter Speck
• Understanding viral and host determinants that influence infection outcomes for influenza A virus in human macrophages  - Kevin Tang
• Investigating the functional diversity of Hendra virus genotypes - Melanie Tripp
• Exploring the Virome of Bats Roosting in the Adelaide Parklands. - Kylie H Van der Hoek
• Development of siRNA therapeutics targeting Human T-cell Leukaemia Virus Type-1 (HTLV-1) infection - Tiana TW Wang
• Antiviral potential of PI3K inhibitors against herpes simplex virus - Natalie Watson
• Cellular Immune Responses Induced by a Chimeric Virus expressing Porcine Reproductive and Respiratory Syndrome Virus-derived peptide - Su-Hwa YOU
• Expanding neutralising antibody breadth with a polyvalent SARS-CoV-2 mRNA vaccine expressing three linked-RBD domains from different variants - Damian Purcell