Norovirus is the most common cause of acute gastroenteritis and is responsible for a major public health burden worldwide. Despite the substantial global health burden and economic impact, there are currently no approved antiviral therapeutics or vaccines. A major barrier to the development of interventions has been, until recently, the lack of efficient in vitro cultivation systems for human norovirus (HNV). Here, we present attempts in the cultivation of HNV using an intestinal organoid culture model. This model will be used to evaluate the neutralising antibody response of samples generated by vaccination of mice with a HNV mRNA vaccine candidate. Due to the difficulties in the cultivation of HNV, much of the research body on norovirus comes from experiments using surrogate viruses, including murine norovirus (MNV). We have established a murine challenge model for MNV, which will be utilised to evaluate the effectiveness of virus-like particle (VLP) vaccines as well as anti-MNV capsid neutralising antibodies, both delivered using mRNA/LNP formulations.