Tuesday, 3rd December 12th Australasian Virology Society Meeting 2024

• CRISPR activation as a tool to identify novel host viral restriction factors - Michael Beard
• Innate immune training in murine model of the post-acute sequelae of COVID-19 - Julian D.J. Sng
• TRIM5 is a critical intrinsic barrier to Powassan virus infection of human cerebral organoids - Byron Shue
• Deficiency in gasdermin cell death proteins limits lung pathology during severe influenza virus infection - Sarah Rosli
• Defining how interferons block recurrent HSV-1 spread from sensory axons - Monica Miranda-Saksena

• Using respiratory tract models to study coronaviruses  - Jessica Neil
• Serotype-Specific Regulation of Dengue Virus NS5 Protein Subcellular Localization - Colin Cheng
• Identification Of Novel Host Proteins That Are Associated With Macrophage Control of Influenza A Virus Replication. - Sarah L Londrigan
• Dissecting viral protein multifunctionality: a path to understanding how deadly RNA viruses remodel the host cell - Angela R Harrison
• Norovirus Protease Targets Host Cell hnRNPK to Enhance Virus Replication - Geena Mckenzie-Goldsmith

• Harnessing the antiviral activities of Pacific traditional medicines. - Natalie E Netzler
• Inhibitor A11N targets the protease region of alphavirus capsid, inhibiting early viral replication and demonstrates broad-spectrum antiviral activity against flaviviruses - Wesley Freppel
• Polyphenol rich sugarcane extract (PRSE) has antiviral activity against influenza A virus in vitro - Caolingzhi Tang
• Defective interfering RNA induces innate immunity and broad-spectrum antiviral activity - Min-Hsuan Lin
• Treatment with Diminazene aceturate, a putative ACE2 activator, reduces immunopathology in severe SARS-CoV-2 and influenza virus infections - Melanie Wu

• The Structural and Antigenic Landscape of Emerging Japanese Encephalitis Serocomplex Flaviviruses - Morgan Freney
• New tools to study viral factors and mechanisms of vertical transmission of insect-specific flaviviruses in mosquitoes - Alyssa Peterson
• Air–Liquid-Interface Human Nasal Epithelium (ALI-HNE) Organoids For Assessing Neutralizing Antibodies To A SARS-Cov-2 Virus-Like Particle Vaccine Candidate - Julio Carrera Montoya
• Using CRISPR-Cas13b as a novel antiviral to target the hepatitis B RNAs to suppress hepatitis B virus replication and protein expression in vitro and in vivo - Laura C McCoullough
• Naturally derived peptides as host-protective treatments for severe influenza - Alison West
• Human macrophages sense replicating, not incoming, influenza A virus in a RIG-I independent manner to drive pro-inflammatory and anti-viral responses. - Larisa Labzin
• Protecting Australia's abalone: A herpesvirus (HaHV-1) defence strategy - Jacinta R Agius

• Harnessing recombinant mosquito-specific viruses to tackle emerging One Health viral diseases - Jody Hobson-Peters
• Dengue virus genomic surveillance in the Applying Wolbachia to Eliminate Dengue (AWED) randomised trial reveals pan-genotype efficacy and disruption of focal virus transmission - Kathryn Edenborough
• A commercial Japanese encephalitis pig vaccine protects against the newly emerged Genotype IV virus         - Caitlin A O'Brien
• Contribution of viral RNA structures to cellular tropism and epizootic emergence of alphaviruses - Jennifer L Hyde
• A Recombinant Alphavirus Platform Based On The Australian Insect-Specific Yada Yada Virus - Mikaela G Bell

• 20 years of research on giant viruses  - Chantal Abergel

Pizzas and beverages will be provided.

Oral presentation posters

The Structural and Antigenic Landscape of Emerging Japanese Encephalitis Serocomplex Flaviviruses (101) - Morgan Freney
New tools to study viral factors and mechanisms of vertical transmission of insect-specific flaviviruses in mosquitoes (103) - Alyssa Peterson
Air–Liquid-Interface Human Nasal Epithelium (ALI-HNE) Organoids For Assessing Neutralizing Antibodies To A SARS-Cov-2 Virus-Like Particle Vaccine Candidate (105) - Julio Carrera Montoya
Using CRISPR-Cas13b as a novel antiviral to target the hepatitis B RNAs to suppress hepatitis B virus replication and protein expression in vitro and in vivo (107) - Laura C McCoullough
Naturally derived peptides as host-protective treatments for severe influenza (109) - Alison West
Human macrophages sense replicating, not incoming, influenza A virus in a RIG-I independent manner to drive pro-inflammatory and anti-viral responses. (111) - Larisa Labzin
Protecting Australia's abalone: A herpesvirus (HaHV-1) defence strategy (113) - Jacinta R Agius

• HUMAN IMMUNODEFICIENCY VIRUS-1 (HIV-1) NEUTRALISATION PROFILES IN HIV-1 VIREMIA SUPPRESSED NEPALESE INDIVIDUALS - Anurag Adhikari
• Computational frameworks guide identification of T cell epitopes: COVID-19 and beyond - Syed Faraz Ahmed
• Evidence of chromosomal translocation, complex integration patterns, and pre-genomic RNA expression in de novo Hepatitis B virus integration - Harout Ajoyan
• Deep Mutational Scanning of SARS-CoV-2 Omicron BA.5 Strain: A Pathway to Pandemic Preparedness - Yousef Alhammad
• The overlap between lipid droplets and extracellular vesicles in viral infection - Irumi I Amarasinghe
• Spatiotemporal Prevalence and Characterisation of the Lineage I Insect-Specific Flavivirus, Quang Binh Virus, Isolated from Culex gelidus Mosquitoes in Singapore - Christopher Chong Wei Ang
• Dynamics of virus infection in a Wolbachia infected host - Angelique Asselin
• Mapping NTD of Spike Protein Utilizing Deep Mutational Scanning to Predict the Unfolding Evolution of SARS-CoV-2 - Yastika Banerjee
• Antigenic characterisation of H7 highly pathogenic avian influenza virus under immunological pressure - Madeline Belfrage
• Exploring the Australian tick virome to determine future zoonotic disease risk - Cameron R Bishop
• Evaluation of Multiple Air Samplers for the Detection of Airborne Viruses - Natasha D Brohier
• Modulation of Germinal Centre and Antibody Dynamics via Ipsilateral Versus Contralateral Immunisation Against SARS-CoV-2 - Lauren Burmas
• Mapping the Dengue Virus NS1 Protein Microenvironment in Infected Cells - Siena Centofanti
• Developing mRNA-based Human T-cell Leukemia Virus type 1 (HTLV-1) Virus-like particle as a vaccine candidate - Yuanhao Chen
• Viral riboswitch structures as therapeutic targets - Vincent Corbin
• Development of bat-differentiated airway epithelium from Pteropus alecto airway epithelial cells - Mithun Das
• CRISPR/Cas13 as an antiviral against influenza virus. - Sudip Dhakal
• Evaluating markers predicting off-treatment wellness and early remission in hepatitis B (EMPOWER-B) - Mark W Douglas
• The Role Of Dicer And Drosha In Maintaining Herpes Simplex Virus Latency - Pathum Ekanayaka
• Development of therapeutics to prevent and treat Norovirus disease - Thalia Frota
• SARS-CoV-2 replication and antibody neutralisation dynamics in vitro  - Matthew Gartner
• The cooperation of Flaviviral Subgenomic RNA (sfRNA) and non-structural protein 5 (NS5) for antagonism of host innate immune response - Jarvis Z.H Goh
• CD8⁺ T cell epitope conservation in emerging H5N1 viruses suggests global protection  - Emma J Grant
• Ago1 is crucial in siRNA-mediated Nuclear RNAi machinery Dynamics of Viral Epigenetic Silencing - Andleeb Hanif
• GALV-KoRV-related retroviruses in diverse Australian and African rodent species - Joshua A Hayward
• Chronic inflammation and T-cell exhaustion ubiquitous in Central Australian HTLV-1c infection is associated with defective proviruses retaining antisense hbz gene - Ashley Hirons
• Multiple neuraminidase gene mutations in serial samples from an immunocompromised influenza A(H3N2) infected patient treated with oseltamivir - Saira Hussain
• The molecular mechanisms of axon degeneration in flavivirus infection - Heather Irving
• Epidemiology and Ecology of Nipah Virus Spillover Events in Bangladesh   - Ariful Islam
• Investigating editing of HBV DNA in vitro and in vivo using a CRISPR/Cas9 Base Editor approach - Zak Janetzki
• Integrating a chimeric Binjari virus nanotechnology into paper-based assays for POC detection of flaviviral infections in veterinary applications - Ryan Johnston
• Selective viral modulation of IFN-regulated genes to suppress antiviral genes while permitting pro-viral gene expression - Alebachew M Kebede
• Complete inactivation of Flavi- and Alphaviruses by acetone for safe titering by ELISA - Robson Kriiger Loterio
• Analysis of H5NX Avian influenza diffusion, evolution and recombination in South-East Asia  - Callum Le Lay
• Inactivation of Airborne Virus Infectivity Using Ultraviolet Light Devices - Leo YY Lee
• A Rapid Pipeline for High Throughput Nanobody Discovery for Viral Glycoproteins via Fluorescence-Activated Cell Sorting of Surface-displayed Bacteria - Benjamin Liang
• Longitudinal sampling of common Sydney market fish reveals limited cross-species virus transmission and no temporal trends in viral abundance and diversity - Lauren Lim
• Recovery of monoclonal antibodies from children with hepatitis associated with adeno-associated virus infection. - Grant J Logan
• Development of ex vivo models of nasal epithelia to elucidate the mechanism of Bordetella bronchiseptica-mediated blockade of influenza virus replication in the nasal cavity. - Jasmina M Luczo
• Australian Animal Pathogen Genomics – a Bioplatforms Australian National Initiative program - Stacey Lynch
• Genome-wide CRISPR knockout screen to identify host factors in avian influenza virus infection - Debolina Majumdar
• Emergence and Molecular Characterisation of a Novel Variant of Infectious Bronchitis Virus in Poultry from Victoria, Australia - Karim Mardani
• Developing a reverse genetics system and antibody tools for the novel insect-specific Negevirus, Castlerea virus - Isabella E McMahon
• The Australian Biosecurity Genomic Database - Peter T Mee
• Cryo-EM structure of bat influenza haemagglutinin - Naphak Modhiran
• Artificial Lipid Droplets as a Novel Antiviral Lipid Particle Delivery System In Vivo. - Ebony A Monson
• Understanding the factors that influence SARS-CoV-2 neutralising antibody titres - Francesca Mordant
• Further insights into asymptomatic outcome after SARS-CoV-2 in HLA-B*15:01+ individuals - Lawton L.M Murdolo
• Investigating the Pathway and Mechanism of Silent HIV Reactivation by IFNα8  - Najla Nasr
• PlexPlus® mass multiplex assay detects 14 viral respiratory targets in a single well - Mia Nguyen
• Does Australian wildlife support transmission of Japanese encephalitis virus? Possum-bly - Caitlin A O'Brien
• Next-generation approach to Lagovirus surveillance in Australia - Nias Y.G. Peng
• CRISPR-Cas approaches targeting the HBV X-antigen as a novel therapeutic. - Romaine Perera
• Intrinsically Stable, Soluble Sarbecovirus Spike Trimers with Enhanced Ability to Elicit Protective Neutralizing Antibody Responses - Andy Poumbourios
• Seasonal antigenic prediction of influenza A H3N2 using machine learning - Ahmed Abdul Quadeer
• Understanding the initial and progressive interactions of Herpes simplex virus with keratinocytes, dendritic cells and cutaneous nerves in human inner foreskin explants - Hafsa Rana
• TMEM106B-mediated SARS-CoV-2 infection allows for robust ACE2-independent infection in vitro but not in vivo - Daniel J. Rawle
• Insect-specific Viruses as Agents to Reduce the Mosquito Vector Competence for Arboviruses - Hayden J Rohlf
• Elucidating the Immune Response to the transboundary Lumpy Skin Disease Virus - Caroline Royle
• Structural characterisation of anti-JEV human antibody epitopes reveals a new target for broad spectrum therapies and vaccines. - Connor Scott
• A role for the actin-binding protein palladin in respiratory syncytial virus infection - Shadi Shahriari
• Reproductive Effects of Male Pigs with a Modified Viral Vaccine Candidate - Jihye Shin
• Characterisation of in ovo infection by infectious laryngotracheitis virus; a comparison of molecular detection, histopathology and light-sheet fluorescence microscopy approaches - Matthew W Smallridge
• Nucleolar Hendra Virus Interactions Visualised By Expansion Microscopy - Nathan Sos
• The prospect of developing a herpesvirus vector vaccine for Australian flying foxes (Pteropus spp.) to reduce the risk of zoonotic diseases - Jennifer Sullivan
• Characterisation of infectious laryngotracheitis virus recombination in chickens vaccinated using different vaccination strategies - Walter Tsang
• Identification of molecular factors that influenced reassortment and the emergence of the 1957 and 1968 pandemic influenza viruses - Mingyang Wang
• Targeted protein degraders of SARS-CoV-2 main protease demonstrate superior antiviral activity over enzymatic inhibition alone - Nadia Warner
• A fatal case of herpesvirus in an Asian elephant in Australia - Jack W Wheelahan
• Genetic diversity of Porcine Reproductive and Respiratory Syndrome Virus in Korea from 2018 to 2022 - Su-Hwa YOU
• A Tiled Amplicon Method For Whole-genome and Targeted Oxford Nanopore Sequencing of African Swine Fever Virus (ASFV) in Timor-Leste - Linda Zheng
• Genome expansion, segmentation and innovations in the evolutionary history of novel Alphaviruses. - Rhys H Parry
• Early circulating biomarkers to predict plasma leakage in dengue fever - Samaneh Moallemi
• Structural determinants of rotavirus virion proteolytic activation - Daniel Luque Buzo
• Development of a high-yield, molecular clamp stabilized, subunit vaccine for H5N1 Highly Pathogenic Avian Influenza (HPAI) in preparation for potential human pandemic - Nicolas Tardiota
• mRNA delivery of ultra-potent HIV broadly neutralising monoclonal antibodies with engineered Fc-regions for expanded immune function. - Damian Purcell
• Bayesian genomic networks for investigating viral disease outbreaks: an example of a highly pathogenic avian influenza (HPAI) outbreak on multiple poultry farms - Stacey Lynch